A 501 by 9 data matrix of a contingency table processed from the FDA Adverse Event Reporting System (FAERS) database. This dataset covers a specific period from Q1 2021 to Q4 2023.
Details
A 501 by 9 data matrix of a contingency table from the FDA Adverse Event Reporting System (FAERS) database, covering the period from Q1 2021 to Q4 2023.
The 500 rows correspond to the AEs with the highest overall frequency (row marginals) reported during the period, and 1 row for Other AEs. The reported AEs - "Off label use" and "Drug ineffective" have been excluded.
The dataset includes the following 9 columns: Acebutolol, Atenolol, Bisoprolol, Carvedilol, Metoprolol, Nadolol, Propranolol, Timolol, and Other.
The marginal totals for each column are as follows: Acebutolol: 62,164, Atenolol: 36,619, Bisoprolol: 134,297, Carvedilol: 35,922, Metoprolol: 88,387, Nadolol: 11,191, Propranolol: 56,444, Timolol: 16,077, Other: 76,926,859.
Also refer to the supplementary material of:
Ding, Y., Markatou, M., & Ball, R. (2020). An evaluation of statistical approaches to postmarketing surveillance. Statistics in Medicine, 39(7), 845-874
for the data generation process. The quarterly files can be found in https://fis.fda.gov/extensions/FPD-QDE-FAERS/FPD-QDE-FAERS.html.
Examples
data(betablocker500)
head(betablocker500)
#> Acebutolol Atenolol Bisoprolol Carvedilol Metoprolol
#> Pain 3582 455 977 110 457
#> Fatigue 0 503 1830 621 1191
#> Nausea 13 994 1313 122 816
#> Arthralgia 10 502 892 131 617
#> Condition aggravated 1 474 409 90 365
#> Dyspnoea 1122 305 2368 549 1702
#> Nadolol Propranolol Timolol Other
#> Pain 307 166 348 1074063
#> Fatigue 34 459 79 1015237
#> Nausea 349 1023 51 757910
#> Arthralgia 17 188 42 688797
#> Condition aggravated 7 359 393 679423
#> Dyspnoea 76 411 385 672028